鞏固肌底

30%
使用4周后肌膚彈力即可最大改善30%*

減少皺紋

50%
使用8周后肌膚細紋即可最多減退50%**

維持皮膚膠原均衡

65%
使用8周后肌膚膠原水平即可提升65%**
科學突破

近期的一項臨床醫學研究報告已讓我們對於如何能夠最有效地通過合理的膳食營養補充來保護我們的肌膚有了全新的認識。

這些刊登在著名國際醫學期刊 Skin Pharmacology and Physiology 的研究表明,攝入特定的膠原肽可以有效增加肌膚彈性*, 減少皺紋數量**,提升原膠原水平**。

研究中所使用的膠原肽是經過特殊生物科技工藝加工而成,可使天然的長鏈膠原酶水解為純淨的含有特殊氨基酸的短肽鏈,這也是為該研究材料與普通粗制膠原肽最大的不同。

研究成果

顯著提升肌膚彈性

30%
使用4周后肌膚彈力即可最大改善30%*

顯著減少皺紋

50%
使用8周后肌膚細紋即可最多減退50%**

顯著增加肌膚原膠原水平

65%
使用8周后肌膚膠原水平即可提升65%**

這些研究都是在高質量嚴要求的標准下進行的, 幾項研究均為隨機雙盲人類觀察性研究並遵照了GCP(Good Clinical Practice) 實驗標准。

該項研究結合之前的科學研究,都已經表明膠原肽隻有在經過保証其效用的特殊加工后才可直達肌膚深層細胞,產生理想效果。這些膠原肽是由特殊工藝製成,該工藝可以將天然長鏈膠原酶水解為一定長度的含有熱頂氨基端序列的短鏈蛋白。

* “在一項雙盲隨機性(興奮劑對比控制的)觀測中,69位參與者在每日攝入特定膠原肽4周后,皮膚彈性均呈現明顯改善,某些個例中彈性提升高達30%。”
[1] Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study. Skin Pharmacol Physiol 2014; 27:47-55.
** “在一項雙盲隨機性(興奮劑對比控制的)觀測中,114位參與者在每日攝入特定膠原肽8周后,眼部皺紋明顯減少,某些個例中皺紋數量減少高達50%。相同臨床研究還表明,多數參與者皮膚內的原膠原含量水平顯著提高(65%)。”
[2] Proksch E, et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol 2014; 27:113–119.

改善女性肌膚彈力 (50+):

graph2
科學背景

00015

這些來自雙盲隨機安慰劑對照觀察性研究的結果,同時也被許多其他體內或體外的臨床前及臨床研究所支持。

研究表明膠原肽能夠以其天然的肽結構被人體迅速吸收[3],[4] 並被血液[6],[7],[8],[9]輸送至皮膚[5] 。一些研究還表明膠原肽可能會影響皮膚自身的膠原產生細胞—成纖維細胞[10],[11],[12], 因而刺激細胞提升膠原及其他接地組織的轉化率[2],[13],[14],[15],[16],[17]。最后,還有一些科學研究表明,攝入膠原肽有助於皮膚的水分平衡[18],[19],[20], 平紋減皺[2],[21],[22],[23] 和彈性提升[1],[18],[24].

[1] Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: A double-blind, placebo-controlled study. Skin Pharmacol Physiol 2014; 27:47-55.
[2] Proksch E, et al. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol 2014; 27:113–119.
[3] Oesser S, et al. Oral administration of 14C-labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage in mice (C57/BL). J Nutr 1999;129:1891-1895.
[4] Zague V. A new view concerning the effects of collagen hydrolysate on skin properties. Arch Dermatol Res 2008; 300:479-483.
[5] Kawaguchi T, et al. Distribution of prolylhydroxyproline and its metabolites after oral administration in rats. Biol Pharm Bull 2012;35(3):422-427.
[6] Ohara H, et al. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J Agric Food Chem 2007;55:1532-1535.
[7] Iwai K, et al. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem 2005;53:6531-6536.
[8] Ichikawa S, et al. Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate. Inter J Food Sci Nutr 2010;61(1):52-60.
[9] Watanabe-Kamiyama M, et al. Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J Agric Food Chem 2010;58(2):835-841.
[10] Shigemura Y, et al. Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin. J Agric Food Chem 2009;57:444-449.
[11] Ohara H, et al. Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermatol 2010;37(4):330-338.
[12] Postlethwaite AE, et al. Chemotactic attraction of human fibroblasts to type I, II and III collagen and collagen-derived peptides. Proc Acad Sci USA 1978;75:871-875.
[13] Rousselot SAS, unpublished data, 2012, Clinical study, Cosderma, France.
[14] Matsuda N, et al. Effects on ingestion of collagen peptide on collagen fibrils and glucosaminoglycans in the dermis. J Nutr Sci Vitaminol (Tokyo) 2006;52:211-215.
[15] Tanaka M, et al. Effects of collagen peptide ingestion on UVB-induced skin damage. Biosci Biotechnol Biochem 2009;73:930-932.
[16] Zague V, et al. Collagen hydrolysate intake increases skin collagen expression and suppress matrix collagenase 2 activity. J Med Food 2011;14:618-624.
[17] Minaguchi J, et al. Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in Achilles tendon. J Nutr Sci Vitaminol (Tokyo) 2005;51:169-174.
[18] Kikuchi K, Matahira Y. Efficacy of orally-ingested marine collagen peptide on dryness and roughness of the human skin. Fragrance Journal 2003;9:97-102.
[19] Rousselot SAS, unpublished data, 2008, Clinical study, Souken, Japan.
[20] Shimizu J, et al. Oral collagen-derived dipeptides, prolyl-hydroxyproline, ameliorate skin barrier dysfunction and alter gene expression profiles in the skin. Biochem Biophys Res Commun 2015;456(2):626-630.
[21] Pyun HB, et al. Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice. Prev Nutr Sci 2012;17(4):245-253.
[22] Borumand M, Sibilla S. Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles. J Med Nutr Nutraceut 2015;4:47-53.
[23] Rousselot SAS, unpublished data, 2008, Clinical study, Dermscan, France.
[24] Oba C, et al. Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice. Photodermatol Photoimmunol Photomed 2013;29(4):204-211.